Dr. Bindu Nanduri

Dr. Bindu Nanduri

Department

  • Comparative Biomedical Sciences

Title

  • Professor

Contacts

bnanduri@cvm.msstate.edu
Office: (662) 325-5859
R1106b

Overview

Education:

  • Doctor of Philosophy (Ph.D.), Biochemistry, University of Arkansas Medical Sciences, 1998
  • Master of Science (M.S.), Biochemistry, University of Rookee, 1992
  • Bachelor of Science (B.S.), Botany, , 1989

Publications

  • Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.. BMC bioinformatics. Volume 18, Issue Suppl 14, Page 498. 2017

Conference Proceeding

  • Digital mRNA profiling of high-risk beef cattle at arrival substantiates markers of bovine respiratory disease.  Conference of Research Workers in Animal Diseases (CRWAD). 2021
  • Multipopulational transcriptomic analysis of high-risk beef cattle on arrival reveals genes and mechanisms which may predict bovine respiratory disease.  American Association of Bovine Practitioners. 2021
  • Hematological network analysis defines mechanisms associated with bovine respiratory disease and performance. Conference of Research Workers in Animal Diseases .  Conference of Research Workers in Animal Diseases (CRWAD). 2020
  • Increased expression of viral defense genes at arrival may contribute to BRD-associated mortality.  Conference of Research Workers in Animal Diseases . 2019
  • Whole blood RNA-seq analysis at arrival to identify biomarkers of respiratory disease risk in stocker cattle.  Conference of Research Workers in Animal Diseases . 2019
  • Whole blood RNA-Seq analysis of stocker calves reveals insights into BRD.  Conference of Research Workers in Animal Diseases . 2019
  • Whole blood RNA-Seq analysis of stocker calves at arrival provides immunological and metabolic distinction related to BRD.  2019 Bovine Respiratory Disease Symposium . 2019
  • Whole blood transcriptome analysis reveals altered pathways related to inflammation and fatty acid metabolism in stocker calves that develop bovine respiratory disease.  International Veterinary Immunology Symposium . 2019
  • On-arrival blood transcriptomes identify altered immune pathways in stocker cattle that develop bovine respiratory disease.  American College of Veterinary Internal Medicine Forum . 2019

Editorial

  • Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.. BMC bioinformatics. Volume 17, Issue Suppl 13, Page 356. 2016

Journal Article

  • Multipopulational transcriptome analysis of post-weaned beef cattle at arrival further validates candidate biomarkers for predicting clinical bovine respiratory disease. Scientific Reports. Volume 11, Issue 1, Page 23877. 2021
  • Multipopulational transcriptome analysis of post-weaned beef cattle at arrival further validates candidate biomarkers for predicting clinical bovine respiratory disease. Scientific Reports. Volume 11, Issue 1, Page 23877. 2021
  • No-boundary thinking: a viable solution to ethical data-driven AI in precision medicine.. AI and ethics. Pages 1-9. 2021
  • Genes and regulatory mechanisms associated with experimentally-induced bovine respiratory disease identified using supervised machine learning methodology.. Scientific reports. Volume 11, Issue 1, Page 22916. 2021
  • The Effect of Impaired Polyamine Transport on Pneumococcal Transcriptome.. Pathogens (Basel, Switzerland). Volume 10, Issue 10. 2021
  • Identification of active deubiquitinases in the chicken tissues . . 2021
  • Comprehensive at-arrival transcriptomic analysis of post-weaned beef cattle uncovers type I interferon and antiviral mechanisms associated with bovine respiratory disease mortality.. PloS one. Volume 16, Issue 4, Page e0250758. 2021
  • Comprehensive at-arrival transcriptomic analysis of post-weaned beef cattle uncovers type I interferon and antiviral mechanisms associated with bovine respiratory disease mortality.. PloS one. Volume 16, Issue 4, Page e0250758. 2021
  • The expansive effects of polyamines on the metabolism and virulence of Streptococcus pneumoniae.. Pneumonia (Nathan Qld.). Volume 13, Issue 1, Page 4. 2021
  • Arginine Decarboxylase Is Essential for Pneumococcal Stress Responses.. Pathogens (Basel, Switzerland). Volume 10, Issue 3. 2021
  • Dosage scaling of alcohol in binge exposure models in mice: An empirical assessment of the relationship between dose, alcohol exposure, and peak blood concentrations in humans and mice.. Alcohol (Fayetteville, N.Y.). Volume 89, Pages 9-17. 2020
  • Towards a unified open access dataset of molecular interactions.. Nature communications. Volume 11, Issue 1, Page 6144. 2020
  • Streptococcus pneumoniae metal homeostasis alters cellular metabolism.. Metallomics : integrated biometal science. Volume 12, Issue 9, Pages 1416-1427. 2020
  • SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae.. Frontiers in microbiology. Volume 11, Page 578533. 2020
  • An atlas of the catalytically active liver and spleen kinases in chicken identified by chemoproteomics.. Journal of proteomics. Volume 225, Page 103850. 2020
  • Proteomic and transcriptional profiling of rat amygdala following social play.. Behavioural brain research. Volume 376, Page 112210. 2019
  • Transcriptomic analysis of early B-cell development in the chicken embryo.. Poultry science. Volume 98, Issue 11, Pages 5342-5354. 2019
  • Adolescent rat social play: Amygdalar proteomic and transcriptomic data.. Data in brief. Volume 27, Page 104589. 2019
  • Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors in Streptococcus pneumoniae. Frontiers in Microbiology. Volume 10. 2019
  • Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors in Streptococcus pneumoniae.. Frontiers in microbiology. Volume 10, Page 1996. 2019
  • Modeling the pasture-associated severe equine asthma bronchoalveolar lavage fluid proteome identifies molecular events mediating neutrophilic airway inflammation.. Veterinary medicine (Auckland, N.Z.). Volume 10, Pages 43-63. 2019
  • Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference.. BMC bioinformatics. Volume 20, Issue Suppl 2, Page 95. 2019
  • Proteogenomic Identification of a Novel Protein-Encoding Gene in Bovine Herpesvirus 1 That Is Expressed during Productive Infection.. Viruses. Volume 10, Issue 9. 2018
  • Leveraging Experimental Details for an Improved Understanding of Host-Pathogen Interactome.. Current protocols in bioinformatics. Volume 61, Issue 1, Pages 8.26.1-8.26.12. 2018
  • The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression.. Medical sciences (Basel, Switzerland). Volume 6, Issue 1. 2018
  • Binge alcohol consumption 18 h after induction of sepsis in a mouse model causes rapid overgrowth of bacteria, a cytokine storm, and decreased survival.. Alcohol (Fayetteville, N.Y.). Volume 63, Pages 9-17. 2017
  • Protein Composition of the Bovine Herpesvirus 1.1 Virion.. Veterinary sciences. Volume 4, Issue 1. 2017
  • Use of focused ultrasonication in activity-based profiling of deubiquitinating enzymes in tissue.. Analytical biochemistry. Volume 515, Pages 9-13. 2016
  • Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia.. Scientific reports. Volume 6, Page 26964. 2016
  • Analysis of differentially expressed proteins in Yersinia enterocolitica-infected HeLa cells.. Biochimica et biophysica acta. Volume 1864, Issue 5, Pages 562-9. 2016
  • The Effect of Oxygen on Bile Resistance in Listeria monocytogenes.. Journal of proteomics & bioinformatics. Volume 9, Issue 4, Pages 107-119. 2016
  • Comparative Proteomic Analysis of Cotton Fiber Development and Protein Extraction Method Comparison in Late Stage Fibers.. Proteomes. Volume 4, Issue 1. 2016
  • Comparative proteomic analysis of cotton fiber development and protein Extraction method comparison in late stage fibers.Protemes. Volume 4, Issue 7, Pages 1-18. 2016
  • Application of Functional Genomics for Bovine Respiratory Disease Diagnostics.. Bioinformatics and biology insights. Volume 9, Issue Suppl 2, Pages 13-23. 2015
  • Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.. PloS one. Volume 10, Issue 8, Page e0135531. 2015
  • Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.. BMC genomics. Volume 16, Page 587. 2015
  • Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project.. Genome biology. Volume 16, Page 57. 2015
  • Big data - a 21st century science Maginot Line? No-boundary thinking: shifting from the big data paradigm.. BioData mining. Volume 8, Page 7. 2015
  • SILAC-based quantitative proteomic analysis of human lung cell response to copper oxide nanoparticles.. PloS one. Volume 9, Issue 12, Page e114390. 2014
  • Identification of canine platelet proteins separated by differential detergent fractionation for nonelectrophoretic proteomics analyzed by Gene Ontology and pathways analysis.. Veterinary medicine (Auckland, N.Z.). Volume 5, Pages 1-9. 2014
  • Proteomic analysis of cross protection provided between cold and osmotic stress in Listeria monocytogenes.. Journal of proteome research. Volume 13, Issue 4, Pages 1896-904. 2014
  • Global analysis of lysine acetylation suggests the involvement of protein acetylation in diverse biological processes in rice (Oryza sativa).. PloS one. Volume 9, Issue 2, Page e89283. 2014
  • Sodium methyldithiocarbamate exerts broad inhibition of cellular signaling and expression of effector molecules of inflammation.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 136, Issue 2, Pages 430-42. 2013
  • No-boundary thinking in bioinformatics research.. BioData mining. Volume 6, Issue 1, Page 19. 2013
  • Ultrasonic incisions produce less inflammatory mediator response during early healing than electrosurgical incisions.. PloS one. Volume 8, Issue 9, Page e73032. 2013
  • Proteomic Analysis of the Response of Listeria monocytogenes to Bile Salts Under Anaerobic Conditions. Journal of Medical Microbiology. Volume 62, Issue 1, Pages 25-35. 2013
  • Deubiquitinating enzymes as promising drug targets for infectious diseases.. Current pharmaceutical design. Volume 19, Issue 18, Pages 3234-47. 2013
  • Role of an iron-dependent transcriptional regulator in the pathogenesis and host response to infection with Streptococcus pneumoniae.. PloS one. Volume 8, Issue 2, Page e55157. 2013
  • Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: confirmatory and novel results in early and late sepsis.. BMC genomics. Volume 13, Page 509. 2012
  • RNA-seq based transcriptional map of bovine respiratory disease pathogen "Histophilus somni 2336".. PloS one. Volume 7, Issue 1, Page e29435. 2012
  • Transcriptome profile of a bovine respiratory disease pathogen: Mannheimia haemolytica PHL213.. BMC bioinformatics. Volume 13 Suppl 15, Page S4. 2012
  • Role of acute ethanol exposure and TLR4 in early events of sepsis in a mouse model.. Alcohol (Fayetteville, N.Y.). Volume 45, Issue 8, Pages 795-803. 2011
  • Proteomic expression profiles of virulent and avirulent strains of Listeria monocytogenes isolated from macrophages.. Journal of proteomics. Volume 74, Issue 10, Pages 1906-17. 2011
  • Alcohol abuse and Streptococcus pneumoniae infections: consideration of virulence factors and impaired immune responses.. Alcohol (Fayetteville, N.Y.). Volume 45, Issue 6, Pages 523-39. 2011
  • Functional modelling of an equine bronchoalveolar lavage fluid proteome provides experimental confirmation and functional annotation of equine genome sequences.. Animal genetics. Volume 42, Issue 4, Pages 395-405. 2011
  • The proteogenomic mapping tool.. BMC bioinformatics. Volume 12, Page 115. 2011
  • TAAPP: Tiling Array Analysis Pipeline for Prokaryotes.. Genomics, proteomics & bioinformatics. Volume 9, Issue 1-2, Pages 56-62. 2011
  • Proteome and membrane fatty acid analyses on Oligotropha carboxidovorans OM5 grown under chemolithoautotrophic and heterotrophic conditions.. PloS one. Volume 6, Issue 2, Page e17111. 2011
  • Aberrantly Expressed Genes in HaCaT Keratinocytes Chronically Exposed to Arsenic Trioxide.. Biomarker insights. Volume 6, Pages 7-16. 2011
  • Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae.. Microbiology (Reading, England). Volume 157, Issue Pt 2, Pages 504-515. 2011
  • Erratum for "Aberrantly Expressed Genes in HaCaT Keratinocytes Chronically Exposed to Arsenic Trioxide".. Biomarker insights. Volume 6, Page 95. 2011
  • Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks.. International journal of inflammation. Volume 2011, Page 176412. 2011
  • Analysis of Bovine Viral Diarrhea Viruses-infected monocytes: identification of cytopathic and non-cytopathic biotype differences.. BMC bioinformatics. Volume 11 Suppl 6, Page S9. 2010
  • GOModeler--a tool for hypothesis-testing of functional genomics datasets.. BMC bioinformatics. Volume 11 Suppl 6, Page S29. 2010
  • HPIDB--a unified resource for host-pathogen interactions.. BMC bioinformatics. Volume 11 Suppl 6, Page S16. 2010
  • Identification of novel non-coding small RNAs from Streptococcus pneumoniae TIGR4 using high-resolution genome tiling arrays.. BMC genomics. Volume 11, Page 350. 2010
  • Gene model detection using mass spectrometry.. Methods in molecular biology (Clifton, N.J.). Volume 604, Pages 137-44. 2010
  • An automated proteomic data analysis workflow for mass spectrometry.. BMC bioinformatics. Volume 10 Suppl 11, Page S17. 2009
  • The transcriptional response of Pasteurella multocida to three classes of antibiotics.. BMC genomics. Volume 10 Suppl 2, Page S4. 2009
  • Experimental annotation of channel catfish virus by probabilistic proteogenomic mapping.. Proteomics. Volume 9, Issue 10, Pages 2634-47. 2009
  • Bovine viral diarrhea virus infection affects the expression of proteins related to professional antigen presentation in bovine monocytes.. Biochimica et biophysica acta. Volume 1794, Issue 1, Pages 14-22. 2009
  • Comparative proteomic analysis of Listeria monocytogenes strains F2365 and EGD.. Applied and environmental microbiology. Volume 75, Issue 2, Pages 366-73. 2009
  • Bovine viral diarrhea viruses differentially alter the expression of the protein kinases and related proteins affecting the development of infection and anti-viral mechanisms in bovine monocytes.. Biochimica et biophysica acta. Volume 1784, Issue 9, Pages 1234-47. 2008
  • Quantitative analysis of Streptococcus pneumoniae TIGR4 response to in vitro iron restriction by 2-D LC ESI MS/MS.. Proteomics. Volume 8, Issue 10, Pages 2104-14. 2008
  • Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility.. BMC systems biology. Volume 2, Page 19. 2008
  • Effects of subminimum inhibitory concentrations of antibiotics on the Pasteurella multocida proteome: a systems approach.. Comparative and functional genomics. Page 254836. 2008
  • Prediction of peptides observable by mass spectrometry applied at the experimental set level.. BMC bioinformatics. Volume 8 Suppl 7, Page S23. 2007
  • ProtQuant: a tool for the label-free quantification of MudPIT proteomics data.. BMC bioinformatics. Volume 8 Suppl 7, Page S24. 2007
  • Bovine germinal vesicle oocyte and cumulus cell proteomics.. Reproduction (Cambridge, England). Volume 133, Issue 6, Pages 1107-20. 2007
  • AgBase: a functional genomics resource for agriculture.. BMC genomics. Volume 7, Page 229. 2006
  • Effects of subminimum inhibitory concentrations of antibiotics on the Pasteurella multocida proteome.. Journal of proteome research. Volume 5, Issue 3, Pages 572-80. 2006
  • Proteomic analysis using an unfinished bacterial genome: the effects of subminimum inhibitory concentrations of antibiotics on Mannheimia haemolytica virulence factor expression.. Proteomics. Volume 5, Issue 18, Pages 4852-63. 2005
  • Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor.. Proceedings of the National Academy of Sciences of the United States of America. Volume 99, Issue 23, Pages 14722-7. 2002
  • Measurement of steady-state kinetic parameters for DNA unwinding by the bacteriophage T4 Dda helicase: use of peptide nucleic acids to trap single-stranded DNA products of helicase reactions.. Nucleic acids research. Volume 29, Issue 13, Pages 2829-35. 2001
  • Evidence for a functional monomeric form of the bacteriophage T4 DdA helicase. Dda does not form stable oligomeric structures.. The Journal of biological chemistry. Volume 276, Issue 23, Pages 19691-8. 2001
  • Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface.. Biochemistry. Volume 38, Issue 37, Pages 11887-94. 1999
  • Role of active-site residues 107 and 108 of glutathione S-transferase mGSTA4-4 in determining the catalytic properties of the enzyme for 4-hydroxynonenal.. Archives of biochemistry and biophysics. Volume 362, Issue 1, Pages 167-74. 1999
  • Mechanism of differential catalytic efficiency of two polymorphic forms of human glutathione S-transferase P1-1 in the glutathione conjugation of carcinogenic diol epoxide of chrysene.. Archives of biochemistry and biophysics. Volume 345, Issue 1, Pages 32-8. 1997
  • Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.. Biochemical and biophysical research communications. Volume 235, Issue 2, Pages 424-8. 1997
  • Amino acid residue 104 in an alpha-class glutathione S-transferase is essential for the high selectivity and specificity of the enzyme for 4-hydroxynonenal.. Archives of biochemistry and biophysics. Volume 335, Issue 2, Pages 305-10. 1996
  • Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.. European journal of biochemistry. Volume 224, Issue 3, Pages 893-9. 1994

Published Erratum

  • Correction: Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.. PloS one. Volume 10, Issue 9, Page e0138635. 2015

Presentations

Abstract

  • "SP1433-1438 Operon of Streptococcus pneumoniae Regulates Metal Homeostasis and Cellular Metabolism during Zinc Stress." Streptococcal Biology Conference, , Newry, ME. 2018
  • "Polyamine transport is essential for evading early host innate immune responses in a mouse model of pneumococcal pneumonia." Southeast Regional IDeA Conference, , Biloxi, MS. 2015
  • "Polyamine transport is essential for evading early host innate immune responses in a mouse model of pneumococcal pneumonia." 12TH European meeting on the molecular biology of the Pneumococcus (EUROPNEUMO 2015), , Oxford, UK. 2015

Oral Presentation

  • "Distinct gene expression patterns associated with BRD identified by statistical and machine learning approaches." Conference of Research Workers in Animal Diseases (CRWAD), CRWAD, Virtual. 2020
  • "Multi-tissue transcriptomic analysis of BRSV-infected cattle using machine learning and statistical approaches." Conference of Research Workers in Animal Diseases (CRWAD), CRWAD, Virtual. 2020
  • "Blood biomarker discovery in high-risk stocker cattle at-arrival: differentiating respiratory health and disease.." Conference of Research Workers in Animal Diseases(CRWAD) , CRWAD, Virtual. 2020
  • "Transcriptomic profiling of BRD-attributed mortality in stocker cattle identifies active inflammatory and antiviral pathways at arrival.." Conference of the American Association of Bovine Practitioners., AABP, Virtual. 2020
  • "A Reanalysis: CBD-Treated Human Neuroblastoma Cells Reveal Potential Mediators in Understanding the Anti-Inflammatory and Neuroprotective Mechanisms.." CVM Research Day, College of Veterinary Medicine, Mississippi State University, College of Veterinary Medicine. 2020
  • "Difluoromethylornithine (DFMO) Inhibits Capsule Biosynthesis in Pneumococci.." CVM Research Day, College of Veterinary Medicine, Mississippi State University, College of Veterinary Medicine. 2020
  • "Impact of impaired polyamine transport on pneumococcal transcriptome and response to hydrogen peroxide stress.." CVM Research Day, College of Veterinary Medicine, Mississippi State University, College of Veterinary Medicine. 2020
  • "Multi-tissue transcriptomic analysis of BRSV-infected cattle using machine learning and statistical approaches.." CVM Research Day, College of Veterinary Medicine, Mississippi State University, College of Veterinary Medicine. 2020

Poster

  • "Multi-tissue transcriptomic analysis of BRSV-infected cattle using machine learning and statistical approaches." National Association of Veterinary Scientists Dual Degree Colloquium., , Virtual. 2020
  • "HPIDB: a curated database for host-pathogen interactions.." International Plant and Animal Genome XXVIII Conference, PAG, San Diego, CA. 2020
  • "Impact of Impaired Polyamine Transport and Biosynthesis on Carbohydrate Metabolism and Identification of Genes Potentially Regulated by Polyamines in Steptococcus pneumoniae." MSU Undergraduate Research Symposium, Shackouls Honors College, Mississippi State University. 2018

Areas of Expertise

Genomics
Bioinformatics
Infectious diseases