Dr. Janice Chambers

Dr. Janice Chambers

Department

  • Comparative Biomedical Sciences
  • Center for Environmental Health Sciences

Title

  • William L. Giles Distinguished Professor

Contacts

chambers@cvm.msstate.edu
Office: (662) 325-1255
Wise Center - R1102

Overview

Education:

  • Doctor of Philosophy (Ph.D.), Animal Physiology, Mississippi State University, 1973
  • Bachelor of Science (B.S.), Biology, University of San Francisco, 1969

Publications

Journal Article

  • Association of serum levels of p,p'- Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi. J Toxicol Environ Health A. Volume 82, Issue 6, Pages 387-400. 2019
  • Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 169, Issue 2, Pages 465-474. 2019
  • A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus. Diabetes Metab Res Rev. Volume 34, Issue 3. 2018
  • Association of type 2 diabetes mellitus with plasma organochlorine compound concentrations. J Expo Sci Environ Epidemiol. Volume 26, Issue 2, Pages 207-13. 2016
  • Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. Toxicol Lett.. Volume 248, Pages 39-45. 2016
  • Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. Toxicology letters. Volume 248, Page 39–45. 2016
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chemico-Biol.. Interact. Volume 259, Pages 154-159. 2016
  • Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Ann N Y Acad Sci.. Volume 1374, Pages 52-58. 2016
  • Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. . Toxicology. Volume 339, Pages 51-57. 2016
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.. Chemico-biological interactions. Volume 259, Issue Pt B, Pages 154-159. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular FractionToxicological Sciences. Volume 150, Issue 1, Pages 169-177. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 150, Issue 1, Pages 169-77. 2016
  • The association of serum trans-nonachlor levels with atherosclerosis.. Journal of toxicology and environmental health. Part A. Volume 79, Issue 5, Pages 210-20. 2016
  • Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiationToxicology Letters. Volume 238, Issue 2, Pages 65-71. 2015
  • Effect of chronic p,p'-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H miceToxicology. Volume 328, Pages 112-122. 2015
  • Paraoxonase 1 polymorphisms within a Mississippi USA population as possible biomarkers of enzyme activities associated with disease susceptibility. Biochem Genet. Volume 52, Issue 11-12, Pages 509-23. 2014
  • Exposure to p,p'-dichlorodiphenyldichloroethylene (DDE) induces fasting hyperglycemia without insulin resistance in male C57BL/6H miceToxicology. Volume 320, Pages 6-14. 2014
  • Relationship of human paraoxonase-1 serum activity and genotype with atherosclerosis in individuals from the Deep South. Pharmacogenet Genomics. Volume 21, Issue 12, Pages 867-875. 2011

Presentations

Poster

  • "Centrally active novel substituted phenoxyalkyl pyridinium oxime reactivators that demonstrate neural protection in rats." 20th Biennial USA Medical Defense Bioscience Review 2016, USA Medical Defense Bioscience Review, Baltimore, MD. 2016
  • "Novel substituted phenoxyalkyl pyridinium oxime reactivators provide improved survival and decreased time to cessation of seizure-like behavior for three organophosphates in rats." 20th Biennial USA Medical Defense Bioscience Review 2016, USA Medical Defense Bioscience Review, Baltimore, MD. 2016
  • "Analysis of rat brain acetylcholinesterase (AChE) reactivation by novel oximes and pralidoxime chloride (2-PAM) after inhibition with a cyclosarin surrogate." 55th Annual Society of Toxicology Meeting, Toxicologist, New Orleans, LA. 2016
  • "Effect of a novel brain-penetrating oxime reactivator on sarin surrogate-induced changes in inflammatory factor gene expression in the rat piriform cortex." 55th Annual Society of Toxicology Meeting, Toxicologist, New Orleans, LA. 2016
  • "In vitro inhibition/reactivation of rat serum butyrylcholinesterase after exposure to nerve agent surrogates and OP insecticidal oxons." 55th Annual Society of Toxicology Meeting, Toxicologist, New Orleans, LA. 2016
  • "Novel substituted phenoxyalkyl pyridinium oximes enhance survival of rats receiving lethal levels of nerve agent surrogates and paraoxon." 55th Annual Society of Toxicology Meeting, Toxicologist, New Orleans, LA. 2016