Dr. Matthew Ross

Dr. Matthew Ross

Title:

  • Professor

Contacts:

mross@cvm.msstate.edu
Office: (662) 325-5482
r1101d

Overview

Summary:

Education
1998 Ph.D., Molecular Toxicology
University of California at Irvine
1989 B.S., Chemistry
University of California at Berkeley

Research and Professional Experience
08/19–Present Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
08/10–7/19 Associate Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
01/04–07/10 Assistant Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
10/99–12/03 Postdoctoral Fellow
Curriculum in Toxicology
University of North Carolina, Chapel Hill
2/98–9/99 Postdoctoral Fellow
Dept. of Community & Environmental Medicine
School of Medicine
University of California, Irvine
9/92–2/98 Research Assistant
Dept. of Community & Environmental Medicine
Environmental Toxicology Graduate Program
School of Medicine
University of California, Irvine
7/89–8/92 Research Chemist/Group Leader
Plant/Soil Metabolism Group
PTRL-West, Richmond, CA

Education:

  • Doctor of Philosophy (Ph.D.), Environmental Toxicology, University of California, Irvine, 1998
  • Bachelor of Science (B.S.), Chemistry, University of California, Berkeley, 1988

Research interests:

The Ross lab seeks to obtain fundamental knowledge of the interactions that occur in immune cells between an enzyme superfamily with a conserved catalytic mechanism – termed the serine hydrolases – and cellular receptors, e.g. PPAR gamma and LXR alpha, that sense endogenous bioactive lipid molecules within the tissue microenvironment. For example, the binding of inflammatory chemicals – which include oxidized lipids called oxylipins and oxysterols – to these lipid-sensing receptors can alter how macrophages (front line sentinel immune cells of the innate immune system) respond in settings of lipid dysfunction and inflammation prevalent in disease states, such as atherosclerosis and lung fibrotic disease. Macrophages exhibit plastic phenotypes that are shaped by the local environment, which can contain several immune-modulating proteins and oxidized small molecules. These phenotypes strongly affect macrophage function in health and disease. The serine hydrolases, which are encoded by over 200 mammalian genes, can regulate the biosynthesis and catabolism of some of these oxidized chemicals in macrophages. We have a keen interest in studying the carboxylesterases, which are serine hydrolase family members that have dual roles in xenobiotic (chemicals that are foreign to the body) and lipid metabolism. Bridging the knowledge gap regarding the immunoregulatory crosstalk we have observed between the carboxylesterase 1 protein and lipid-sensing nuclear receptors in human macrophages will be significant because the links between macrophage polarization state and lipid-driven inflammation are not completely understood. It will enable the acquisition of knowledge to better understand disease states driven by these processes and enable strategies to target them therapeutically.

Biography

Education
1998 Ph.D., Molecular Toxicology
University of California at Irvine
1989 B.S., Chemistry
University of California at Berkeley

Research and Professional Experience
08/19–Present Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
08/10–7/19 Associate Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
01/04–07/10 Assistant Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
10/99–12/03 Postdoctoral Fellow
Curriculum in Toxicology
University of North Carolina, Chapel Hill
2/98–9/99 Postdoctoral Fellow
Dept. of Community & Environmental Medicine
School of Medicine
University of California, Irvine
9/92–2/98 Research Assistant
Dept. of Community & Environmental Medicine
Environmental Toxicology Graduate Program
School of Medicine
University of California, Irvine
7/89–8/92 Research Chemist/Group Leader
Plant/Soil Metabolism Group
PTRL-West, Richmond, CA

Publications

Journal Article

  • Inhibition of fatty acid amide hydrolase by chlorpyrifos in juvenile rats results in altered exploratory and social behavior as adolescents.. Neurotoxicology. Volume 77, Pages 127-136. 2020
  • Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions.. Molecules (Basel, Switzerland). Volume 23, Issue 12. 2018
  • PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected With Salmonella Typhimurium and Yersinia enterocolitica.. Frontiers in microbiology. Volume 9, Page 2447. 2018
  • Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J miceFood and Chemical Toxicology. Volume 118, Pages 821-829. 2018
  • Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J mice.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Volume 118, Pages 821-829. 2018
  • Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity.. Molecular and cellular biochemistry. Volume 444, Issue 1-2, Pages 125-141. 2018
  • Application of the key characteristics of carcinogens in cancer hazard identification.. Carcinogenesis. Volume 39, Issue 4, Pages 614-622. 2018
  • Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1-LXRα signaling.. The Biochemical journal. Volume 475, Issue 3, Pages 621-642. 2018
  • Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice.. Biochimica et biophysica acta. Molecular and cell biology of lipids. Volume 1863, Issue 1, Pages 26-39. 2018
  • Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J miceToxicology and Applied Pharmacology. Volume 337, Pages 67-75. 2017
  • Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice.. Toxicology and applied pharmacology. Volume 337, Pages 67-75. 2017
  • Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs.. American journal of veterinary research. Volume 78, Issue 9, Pages 1025-1035. 2017
  • Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats.. International journal of toxicology. Volume 36, Issue 5, Pages 395-402. 2017
  • Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development.. Neurotoxicology. Volume 59, Pages 183-190. 2017
  • Effects of Leukoreduction and Storage on Erythrocyte Phosphatidylserine Expression and Eicosanoid Concentrations in Units of Canine Packed Red Blood Cells.. Journal of veterinary internal medicine. Volume 31, Issue 2, Pages 410-418. 2017
  • Evaluation of eicosanoid concentrations in stored units of canine packed red blood cells.. Journal of the American Veterinary Medical Association. Volume 250, Issue 2, Pages 191-198. 2017
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chemico-Biol.. Interact. Volume 259, Pages 154-159. 2016
  • Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase.. American journal of physiology. Cell physiology. Volume 311, Issue 6, Pages C960-C974. 2016
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.. Chemico-biological interactions. Volume 259, Issue Pt B, Pages 154-159. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular FractionToxicological Sciences. Volume 150, Issue 1, Pages 169-177. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 150, Issue 1, Pages 169-77. 2016
  • Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics.. Archives of biochemistry and biophysics. Volume 590, Pages 72-81. 2016
  • The association of serum trans-nonachlor levels with atherosclerosis.. Journal of toxicology and environmental health. Part A. Volume 79, Issue 5, Pages 210-20. 2016
  • Oxyradical Stress, Endocannabinoids, and Atherosclerosis.. Toxics. Volume 3, Issue 4, Pages 481-498. 2015
  • Quantification and comparison of baseline cortisol levels between aqueous and plasma from healthy anesthetized hound dogs utilizing mass spectrometry. Veterinary ophthalmology. Volume 17, Issue 1, Page 57–62. 2014
  • Pharmacokinetic evaluation of oral dantrolene in the dogJournal of Veterinary Pharmacology and Therapeutics. Volume 37, Issue 3, Pages 286-294. 2014
  • Evaluation of the ‘side door’ in carboxylesterase-mediated catalysis and inhibitionBiological Chemistry. Volume 389, Issue 2. 2008

comment, editorial

  • Role of lysyl oxidase on microvascular function.. American journal of physiology. Heart and circulatory physiology. Volume 314, Issue 4, Pages H784-H786. 2018

comment, letter

  • Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.. Carcinogenesis. Volume 39, Issue 8, Pages 1091-1093. 2018