Dr. Matthew Ross, PhD

Dr. Matthew Ross, PhD

Title:

  • Professor

Contacts:

mross@cvm.msstate.edu
Office: (662) 325-5482
r1101d

Overview

Summary:

Education
1998 Ph.D., Molecular Toxicology
University of California at Irvine
1989 B.S., Chemistry
University of California at Berkeley

Research and Professional Experience
08/19–Present Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
08/10–7/19 Associate Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
01/04–07/10 Assistant Professor
Mississippi State University
Department of Basic Sciences
Center for Environmental Health Sciences
College of Veterinary Medicine
10/99–12/03 Postdoctoral Fellow
Curriculum in Toxicology
University of North Carolina, Chapel Hill
2/98–9/99 Postdoctoral Fellow
Dept. of Community & Environmental Medicine
School of Medicine
University of California, Irvine
9/92–2/98 Research Assistant
Dept. of Community & Environmental Medicine
Environmental Toxicology Graduate Program
School of Medicine
University of California, Irvine
7/89–8/92 Research Chemist/Group Leader
Plant/Soil Metabolism Group
PTRL-West, Richmond, CA

Education:

  • Doctor of Philosophy (Ph.D.), Environmental Toxicology, University of California, Irvine, 1998
  • Bachelor of Science (B.S.), Chemistry, University of California, Berkeley, 1988

Research interests:

The Ross lab seeks to obtain fundamental knowledge of the interactions that occur in immune cells between an enzyme superfamily with a conserved catalytic mechanism – termed the serine hydrolases – and cellular receptors, e.g. PPAR gamma and LXR alpha, that sense endogenous bioactive lipid molecules within the tissue microenvironment. For example, the binding of inflammatory chemicals – which include oxidized lipids called oxylipins and oxysterols – to these lipid-sensing receptors can alter how macrophages (front line sentinel immune cells of the innate immune system) respond in settings of lipid dysfunction and inflammation prevalent in disease states, such as atherosclerosis and lung fibrotic disease. Macrophages exhibit plastic phenotypes that are shaped by the local environment, which can contain several immune-modulating proteins and oxidized small molecules. These phenotypes strongly affect macrophage function in health and disease. The serine hydrolases, which are encoded by over 200 mammalian genes, can regulate the biosynthesis and catabolism of some of these oxidized chemicals in macrophages. We have a keen interest in studying the carboxylesterases, which are serine hydrolase family members that have dual roles in xenobiotic (chemicals that are foreign to the body) and lipid metabolism. Bridging the knowledge gap regarding the immunoregulatory crosstalk we have observed between the carboxylesterase 1 protein and lipid-sensing nuclear receptors in human macrophages will be significant because the links between macrophage polarization state and lipid-driven inflammation are not completely understood. It will enable the acquisition of knowledge to better understand disease states driven by these processes and enable strategies to target them therapeutically.

Publications

Journal Article

  • Canine Immune Cells Express High Levels of CB1 and CB2 Cannabinoid Receptors and Cannabinoid-Mediated Alteration of Canine Cytokine Production is Vehicle-Dependent. Vet Immunol Immunopathol. 2023
  • Cnr1 Knockout has Minimal Impact on Chlorpyrifos-mediated Effects in the Mouse Endocannabinoid System, but it Does Alter Lipopolysaccharide-induced Cytokine Levels in Splenocytes. Chemico-Biological Interactions. 2023
  • Nanochannel Delivery for CBD Therapy: Sustained Low Level Plasma Levels without Liver Toxicity. J Drug Delivery Sci Technol . 2023
  • Nanochannel delivery system for CBD: Sustained low level plasma levels without liver toxicity. J Drug Deliv Sci Techno. Page 79. 2023
  • CES1 Releases Oxylipins from Oxidized Triacylglycerol (oxTAG) and Regulates Macrophage oxTAG/TAG Accumulation and PGE2/IL-1 Production.. ACS Chemical Biology. 2023
  • Ces1d Inactivation Augments Lung Inflammation in Female Mice. ACS Pharmacol Transl Sci.
  • Evaluation of Electrospun PCL-PLGA for Sustained Delivery of Kartogenin.. Molecules (Basel, Switzerland). Volume 27, Issue 12. 2022
  • Standardized Cannabis Smoke Extract Induces Inflammation in Human Lung Fibroblasts. Front Pharmacol. 2022
  • Effect of washing units of canine red blood cells on storage lesions. Journal of Veterinary Internal Medicine. Volume 36, Issue 1, Pages 66-77. 2022
  • Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice. Chem Res Toxicol. Volume 34, Issue 6, Pages 1556-1571. 2021
  • Inactivation of CES1 Blocks Prostaglandin D2 Glyceryl Ester Catabolism in Monocytes/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E2 Glyceryl Ester Are Attenuated.. ACS omega. Volume 5, Issue 45, Pages 29177-29188. 2020
  • Formulation, pharmacological evaluation, and efficacy studies of occidiofungin, a novel antifungal. Antimicrobial Agents and Chemotherapy. Volume 64, Issue 12. 2020
  • SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae.. Frontiers in microbiology. Volume 11, Page 578533. 2020
  • Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model.. International journal of molecular sciences. Volume 21, Issue 17. 2020
  • Inhibition of fatty acid amide hydrolase by chlorpyrifos in juvenile rats results in altered exploratory and social behavior as adolescents.. Neurotoxicology. Volume 77, Pages 127-136. 2020
  • Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions.. Molecules (Basel, Switzerland). Volume 23, Issue 12. 2018
  • Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions.. Molecules (Basel, Switzerland). Volume 23, Issue 12. 2018
  • PGE2 Augments Inflammasome Activation and M1 Polarization in Macrophages Infected With Salmonella Typhimurium and Yersinia enterocolitica.. Frontiers in microbiology. Volume 9, Page 2447. 2018
  • Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J mice. Food and Chemical Toxicology. Volume 118, Pages 821-829. 2018
  • Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J mice.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Volume 118, Pages 821-829. 2018
  • Endocannabinoid hydrolases in avian HD11 macrophages identified by chemoproteomics: inactivation by small-molecule inhibitors and pathogen-induced downregulation of their activity.. Molecular and cellular biochemistry. Volume 444, Issue 1-2, Pages 125-141. 2018
  • Application of the key characteristics of carcinogens in cancer hazard identification.. Carcinogenesis. Volume 39, Issue 4, Pages 614-622. 2018
  • Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1-LXRα signaling.. The Biochemical journal. Volume 475, Issue 3, Pages 621-642. 2018
  • Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice.. Biochimica et biophysica acta. Molecular and cell biology of lipids. Volume 1863, Issue 1, Pages 26-39. 2018
  • Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. Toxicology and Applied Pharmacology. Volume 337, Pages 67-75. 2017
  • Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice.. Toxicology and applied pharmacology. Volume 337, Pages 67-75. 2017
  • Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs.. American journal of veterinary research. Volume 78, Issue 9, Pages 1025-1035. 2017
  • Inhibition of Endocannabinoid-Metabolizing Enzymes in Peripheral Tissues Following Developmental Chlorpyrifos Exposure in Rats.. International journal of toxicology. Volume 36, Issue 5, Pages 395-402. 2017
  • Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development.. Neurotoxicology. Volume 59, Pages 183-190. 2017
  • Effects of Leukoreduction and Storage on Erythrocyte Phosphatidylserine Expression and Eicosanoid Concentrations in Units of Canine Packed Red Blood Cells.. Journal of veterinary internal medicine. Volume 31, Issue 2, Pages 410-418. 2017
  • Evaluation of eicosanoid concentrations in stored units of canine packed red blood cells.. Journal of the American Veterinary Medical Association. Volume 250, Issue 2, Pages 191-198. 2017
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX. Chemico-Biol.. Interact. Volume 259, Pages 154-159. 2016
  • Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase.. American journal of physiology. Cell physiology. Volume 311, Issue 6, Pages C960-C974. 2016
  • Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.. Chemico-biological interactions. Volume 259, Issue Pt B, Pages 154-159. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction. Toxicological Sciences. Volume 150, Issue 1, Pages 169-177. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 150, Issue 1, Pages 169-77. 2016
  • Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics.. Archives of biochemistry and biophysics. Volume 590, Pages 72-81. 2016
  • The association of serum trans-nonachlor levels with atherosclerosis.. Journal of toxicology and environmental health. Part A. Volume 79, Issue 5, Pages 210-20. 2016
  • Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation.. Prostaglandins & other lipid mediators. Volume 121, Issue Pt B, Pages 199-206. 2015
  • Oxyradical Stress, Endocannabinoids, and Atherosclerosis.. Toxics. Volume 3, Issue 4, Pages 481-498. 2015
  • Pharmacokinetics and pharmacodynamics comparison between subcutaneous and intravenous butorphanol administration in horses. Journal of Veterinary Pharmacology and Therapeutics. Volume 38, Issue 4, Pages 365-374. 2015
  • Quantification and comparison of baseline cortisol levels between aqueous and plasma from healthy anesthetized hound dogs utilizing mass spectrometry. Veterinary ophthalmology. Volume 17, Issue 1, Page 57–62. 2014
  • Low level chlorpyrifos exposure increases anandamide accumulation in juvenile rat brain in the absence of brain cholinesterase inhibition.. Neurotoxicology. Volume 43, Pages 82-89. 2014
  • Pharmacokinetic evaluation of oral dantrolene in the dog. Journal of Veterinary Pharmacology and Therapeutics. Volume 37, Issue 3, Pages 286-294. 2014
  • Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure.. Toxicological Sciences. Volume 135, Issue 1, Pages 193-201. 2013
  • Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats.. Toxicological Sciences. Volume 122, Issue 1, Pages 112-20. 2011
  • Evaluation of the ‘side door’ in carboxylesterase-mediated catalysis and inhibition. Biological Chemistry. Volume 389, Issue 2. 2008

comment, editorial

  • Role of lysyl oxidase on microvascular function.. American journal of physiology. Heart and circulatory physiology. Volume 314, Issue 4, Pages H784-H786. 2018

comment, letter

  • Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.. Carcinogenesis. Volume 39, Issue 8, Pages 1091-1093. 2018

Presentations

Abstract

  • "Carboxylesterase 1 (CES1) regulates arachidonic acid-containing triacylglycerol levels in macrophages and shapes their immunophenotype.." American Society for Biochemistry and Molecular Biology (ASBMB), ASBMB, Seattle, WA. 2023
  • "RUMEN DYNAMICS OF VOLATILE FATTY ACIDS AND EPICHLOË COENOPHIALA-PRODUCED ERGOVALINE IN STEERS GRAZING ON TALL FESCUE." Conference of Research Workers in Animal Diseases (CRWAD), CRWAD, Chicago, IL. 2023
  • "Carboxylesterase 1 (CES1) regulates arachidonic acid-containing triacylglycerol levels in macrophages and shapes their immunophenotype. Abstract presented at the Mississippi Academy of Sciences." MS Academy of Sciences, MS Academy of Sciences, Biloxi, MS. 2023

Poster

  • "Bioprinting and evaluation of PLGA-KGN scaffolds as an augmentation to microfracture." Virtual Undergraduate Research Symposium, Mississippi State University, Mississippi State, MS. 2021
  • "Immune Effects of Carboxylesterase Inactivation in the Neonatal Murine Lung. ." Society of Toxicology, SOT, canceled. 2020
  • "Immune Effects of Carboxylesterase Inactivation in the Neonatal Murine Lung. ." Society of Toxicology South Central Regional Chapter Annual Meeting, Society of Toxicology South Central Regional Chapter , Starkville, MS. 2020
  • "The Action of PGD2-G and PGD2 on genes in the IL-4 pathway and on those regulated by the PPAR and DP1 receptors in human THP-1 macrophages.." South Central Chapter of Society of Toxicology Annual Meeting, South Central Chapter of Society of Toxicology, Starkville, MS. 2020