Dr. Steve Pruett

Dr. Steve Pruett

Department

  • Comparative Biomedical Sciences

Title

  • Professor and Director of NIH Center of Biomedical Research Excellence

Contacts

sbp7@msstate.edu
Office: (662) 325-6653
r2008

Overview

Summary:

Dr. Pruett's research has been supported for 30 years by nationally competitive grants, mostly from the National Institutes of Health. He has served as major professor for 24 graduate students. He has published 125 peer-reviewed papers. He has served on more than 30 NIH grant review panels and on the editorial board for several journals including the Journal of Immunology and Toxicological Sciences.

Education:

  • Doctor of Philosophy (Ph.D.), Immunology, LSU Health Shreveport, 1980
  • Bachelor of Science (B.S.), Microbiology, Northwestern State University of Louisiana, 1976

Research interests:

Innate Immunity and Inflammation
Anti-fungal Drugs
Toll-Like Receptors
Effects of Drugs, Chemicals, and Stressors on the Immune System
Immunotoxicology
Sepsis

Publications

Journal Article

  • Dosage scaling of alcohol in binge exposure models in mice: An empirical assessment of the relationship between dose, alcohol exposure, and peak blood concentrations in humans and mice.. Alcohol (Fayetteville, N.Y.). Volume 89, Pages 9-17. 2020
  • Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.. Journal of immunology (Baltimore, Md. : 1950). Volume 200, Issue 2, Pages 669-680. 2018
  • Binge alcohol consumption 18 h after induction of sepsis in a mouse model causes rapid overgrowth of bacteria, a cytokine storm, and decreased survival.. Alcohol (Fayetteville, N.Y.). Volume 63, Pages 9-17. 2017
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular FractionToxicological Sciences. Volume 150, Issue 1, Pages 169-177. 2016
  • Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 150, Issue 1, Pages 169-77. 2016
  • Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 145, Issue 2, Pages 214-32. 2015
  • Evaluating the incidence of gastrocnemius tendon rupture in broiler chickens The effects of cyclosporine on platelet function and cyclooxygenase expression in normal dogs. International journal of poultry science. Volume 12, Issue 12, Pages 685-688. 2013
  • Sodium methyldithiocarbamate exerts broad inhibition of cellular signaling and expression of effector molecules of inflammation.. Toxicological sciences : an official journal of the Society of Toxicology. Volume 136, Issue 2, Pages 430-42. 2013
  • The Effects of Cyclosporine on Platelet Function and Cyclooxygenase Expression in Normal DogsJournal of Veterinary Internal Medicine. Volume 26, Issue 6, Pages 1389-1401. 2012
  • Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: confirmatory and novel results in early and late sepsis.. BMC genomics. Volume 13, Page 509. 2012
  • Role of acute ethanol exposure and TLR4 in early events of sepsis in a mouse model.. Alcohol (Fayetteville, N.Y.). Volume 45, Issue 8, Pages 795-803. 2011
  • Pharmacodynamic Monitoring of Canine T-Cell Cytokine Responses to Oral CyclosporineJournal of Veterinary Internal Medicine. Volume 25, Issue 6, Pages 1391-1397. 2011
  • Pharmacodynamic Monitoring of Canine T-Cell Cytokine Responses to Oral CyclosporineJournal of Veterinary Internal Medicine. Volume 25, Issue 6, Pages 1391-1397. 2011
  • Alcohol abuse and Streptococcus pneumoniae infections: consideration of virulence factors and impaired immune responses.. Alcohol (Fayetteville, N.Y.). Volume 45, Issue 6, Pages 523-39. 2011
  • Platelet Cyclooxygenase Expression in Normal DogsJournal of Veterinary Internal Medicine. Volume 25, Issue 5, Pages 1106-1112. 2011
  • An innate immune regulatory factor (IIRF) prevents tumorogenesis in a murine melanoma challenge model. Drug development research. Volume 64, Issue 4, Page 213–219. 2005

Areas of Expertise

Immunology
Infectious diseases
ethanol immuotoxicity
pesticide immunotoxicity